CYP2J2 Expression and Circulating Epoxyeicosatrienoic Metabolites in Preeclampsia
نویسندگان
چکیده
Florian Herse, PhD; Babbette LaMarca, PhD; Carl A. Hubel, PhD; Tea Kaartokallio, MSc; A. Inkeri Lokki, MSc; Eeva Ekholm, MD, PhD; Hannele Laivuori, MD, PhD; Martin Gauster, PhD; Berthold Huppertz, PhD; Meryam Sugulle, MD; Michael J. Ryan, PhD; Sarah Novotny, MD; Justin Brewer, MD; Joon-Keun Park, PhD; Michael Kacik, MD; Joachim Hoyer, MD; Stefan Verlohren, MD; Gerd Wallukat, PhD; Michael Rothe, PhD; Friedrich C. Luft, MD; Dominik N. Muller, PhD; Wolf-Hagen Schunck, PhD; Anne Cathrine Staff, MD, PhD; Ralf Dechend, MD
منابع مشابه
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
BACKGROUND Preeclampsia is a multisystem disorder of pregnancy, originating in the placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are mechanistically important in preeclampsia. METHODS AND RESULTS We performed microarray screening of placenta and decidua (maternal placenta) from 25 preeclamptic women and 23 control subje...
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Epoxyeicosatrienoic acids (EETs) and arachidonic acid-derived cytochrome P450 (CYP) epoxygenase metabolites have diverse biological effects, including anti-inflammatory properties in the vasculature. Increasing evidence suggests that inflammation in type 2 diabetes is a key component in the development of insulin resistance. In this study, we investigated whether CYP epoxygenase expression and ...
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Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy and heart failure, which involve the activation of 5'-AMP-activated protein kinase (AMPK) and Akt. Although the functional roles of AMPK and Akt are well established, the significance of cross talk between them in the development of cardiac hypertrophy and antihypertrophy of CYP...
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CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective properties. This study was designed to examine the role of CYP2J2 in hypoxia-reoxygenation-induced injury in cultured bovine aortic endothelial cells (BAECs). Early passage BAECs were exposed to 24-h hypoxia followed by 4-h...
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Prolonged endoplasmic reticulum (ER) stress causes apoptosis and is associated with heart failure. Whether CYP2J2 and its arachidonic acid metabolites [epoxyeicosatrienoic acids (EETs)] have a protective influence on ER stress and heart failure has not been studied. Assays of myocardial samples from patients with end-stage heart failure showed evidence of ER stress. Chronic infusion of isoprote...
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